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Like Uloric, Krystexxa does not appear dependent on the kidney to be removed from the body, allowing it to be considered in patients with decreased kidney function

GLP-1 agonists, such as semaglutide or tirzepatide, act on the GLP-1 receptor to suppress appetite and to regulate glycemia

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(More information) The long-term use of certain medications, such as inhibitors of stomach acid secretion and the anti-diabetes drug, metformin, can adversely affect vitamin B 12 absorption

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10.1007/s10620-008-0332-9 130 SkorjanecS.KokotA.DrmicD.RadicB.SeverM.KlicekR.et al (2015)