Michael Snyder, medical director of the Denver Center for Weight Loss and Bariatric Surgery Center at Rose Medical Center and in-house obesity specialist at FuturHealth, "just because someone else had success with these medications doesn't mean that everyone willIt's physiology." Flow Space spoke with experts to learn some of the unexpected reasons why someone who is following their doctor's instructions may not have success on GLP-1s and to provide some suggetions to fix them
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Again, the overlap complicates assessment
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The dual mechanism adds : GIP receptor activation (influences insulin secretion and energy metabolism) Potentially complementary effects on appetite and fat storage Weekly injection schedule Different side effect profile in some individuals Critical Understanding: The clinical data referenced above comes from FDA-approved branded products (Ozempic, Wegovy, Mounjaro, Zepbound) that underwent extensive clinical trials
In patients with Type 2 diabetes and established cardiovascular disease, GLP-1RAs reduced the incidence of major adverse cardiovascular events (MACE), including heart attack and stroke (Marso et al., 2016, NEJM)