At the same time, he said these therapies may offer additional benefits for liver disease
Obesity and T2DM could contribute to EOCRC through insulin resistance and/or hyperinsulinaemia, chronic inflammation and altered gut microbiome, which create a pro-tumorigenic environment that accelerates colorectal carcinogenesis
GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) are contraindicated during breastfeeding per UK Summary of Product Characteristics No weight loss injection currently has regulatory approval for use whilst breastfeeding in the UK Transfer into breast milk and effects on nursing infants remain unknown due to absence of human studies Appetite suppression from these medications may compromise maternal nutrition needed for adequate milk production Safe alternatives include gradual dietary modification, regular physical activity, and NHS weight management programmes Women should defer weight loss medications until breastfeeding is completed and seek GP advice for postpartum weight concerns Table of Contents Weight Loss Injections and Breastfeeding: Key Safety Considerations Types of Weight Loss Injections and Their Use During Lactation Potential Risks to Breastfed Infants Alternative Approaches to Postpartum Weight Management When to Seek Medical Advice About Weight Loss While Breastfeeding Scientific References Frequently Asked Questions Weight Loss Injections and Breastfeeding: Key Safety Considerations Weight loss injections, particularly GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda), have become increasingly popular for weight management
The 6-week escalation protocol This modified schedule takes 24 weeks to reach the full 12mg maintenance dose instead of 16 weeks
In patients with T2D, GLP-1 RAs may improve endothelial function and blood pressure, which can translate to better penile blood flow
Ghrelin/GHSR Agonists: Ipamorelin, GHRP-2, GHRP-6, and Hexarelin The second major category is the growth hormone secretagogue receptor pathway, also known as GHSR-1a
