Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AQ amodiaquine AQ-SG 5-glutathion- S -yl-amodiaquine AQ-QI amodiaquine-quinoneimine BSO L -buthionine-sulfoximine CDNB 1-chloro-2, 4-dinitrobenzene CYP cytochromes P450 DEAQ N -desethylamodiaquine DEAQ-SG 5-glutathion- S -yl- N -desethylamodiaquine DEAQ-QI N -desethylamodiaquine-quinoneimine DMEM Dulbeccos modified Eagle medium DMF N,N -dimethylformamide ER endoplasmic reticulum FBS fetal bovine serum GSH glutathione GSSG glutathione disulfide GST glutathione S -transferase H 2 O 2 hydrogen peroxide HClO 4 perchloric acid HRP horseradish peroxidase NQO1 NAD(P)H:quinone oxidoreductase 1 NAPQI N -acetyl- p -benzoquinonimine PBS phosphate-buffered saline QI quinoneimine

(b) Xpert HCV Viral Load (VL) test results corrected for same-day haematocrit [+log 10 (1000/(100haematocrit(%))] sd = standard deviation, Hct = haematocrit Figure S3 Bland-Altman plot of 14 paired quantifiable HCV RNA measurements: Cobas in 650 l venous plasma versus Xpert HCV Viral Load Finger-Stick (VL FS) test in 100 l capillary whole blood
Key takeaways Nausea is the most common side effect of Wegovy, Zepbound, Ozempic, Mounjaro, and Foundayo, and the most common reason patients in trials and in clinic consider stopping
If overdose is suspected or if neurologic symptoms emerge, stop further dosing and seek medical evaluation
Bacteriostatic water contains a preservative (benzyl alcohol at 0.9%) that prevents bacterial growth
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