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Dividing the doses to optimize efficacy is recommended rather than taking a single large daily dose

For example, brain derived neurotrophic factor (BDNF) and TNF protect neurons against excitotoxicity through activation of the transcription factor NF-kB, which induces the expression of antioxidant enzymes such as Mn-SOD and the anti-apoptotic proteins, Bcl-2 and inhibitor of apoptosis proteins IAPs [123,124]

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Put the three together and the pitch is a loop: supply NAD+, protect NAD+, then flip on the pathways that spend it productively

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Drugs DSIP (H-Trp-Ala-Gly-Gly-Asp-Ala-SerGly-Glu-OH) was synthesized in the Laboratory of Peptide Chemistry, Shemyakin, and the Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, as described elsewhere [26]