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Studies have demonstrated that ferroptosis is closely associated with diabetes-related chronic inflammation, oxidative stress, and cellular damage, all of which collectively influence wound healing

Currently, multiple phase 3 trials with oral semaglutide and orforglipron are ongoing for different populations (NCT05803421), while another oral GLP-1 RA (CT-996) is in early phase clinical trials (Table 1)

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Focus on renal actions and overview of clinical experience