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Quick Answer: Yes, weight loss injections can cause fatigue, which is listed as a common adverse reaction occurring in 5% of patients in FDA prescribing information for both Wegovy and Zepbound

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GLP-1 Drugs and the Brain GLP-1 receptors arent only in your pancreas and gastrointestinal system you also have them in your brain, particularly in the areas that regulate reward, motivation and impulse control

Efficacy of liraglutide for weight loss among patients with type 2 diabetes: National Center for Biotechnology Information

It can also be prescribed for people without type 2 diabetes who need help with insulin resistance or managing blood sugar with other diabetes medications