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Despite its immense potential, the clinical application of metabolomics remains hindered by technical limitations, such as cross-cohort standardization and data interpretation complexity

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Using fibroblasts induced to senesce by ionizing radiation, we further observed that p53 is phosphorylated on Serine 46 and that removing FOXO4 could trigger a clean cell death response, known as apoptosis (de Keizer&Campisi, Cancer Res (2011) 71 (18_Supplement): C35.)

Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A

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M., Mendoza, S., Hamer, T., Sosa, F