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In this context, estrogens can produce reactive oxygen species by increasing mitochondrial activity and redox cycling of estrogen metabolites (Kumar et al., 2010)

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This percentage has remained consistent over the last 10 years

First, FFAs create a high-oxidative state that triggers the release of calcium ions (Ca + ) from the ER, which increases intracellular Ca + concentrations and retroactively activates various digestive enzymes, including trypsin ( Clinical studies have indicated that patients with hypertriglyceridemia-induced AP often experience more severe abdominal pain, higher fever, and markedly increased levels of inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) (32)

Alcohol consumption can exacerbate these gastrointestinal side effects, potentially leading to increased discomfort, dehydration, and poor medication tolerance

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