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Several studies have shown that intramuscular and intravenous B12 delivery is more effective than oral supplementation in people with deficiency or poor absorption

doi: 10.1093/pm/pnab278 97

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References state that the dysbiosis is likely to be responsible for early stage PD GI-related problems, including constipation, with a notable increase in bacterial families that include Lactobacillaceae, Verrucomicrobiaceae, Bradyrhizobiaceae, Bifidobacterium , and Akkermansia (Hashish and Salama, 2023)

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