Arch Biochem Biophys 527(2):113118
The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality
Drug repurposing: far beyond new targets for old drugs
American Society of Plant Biologists, Rockville, MD, p e0142
As such, patients may experience ancillary anti-aging benefits including improved skin elasticity and the diminishment of fine lines
However, it is worth noting that the extent of the increase and the duration for which these elevated levels are maintained could vary between the two