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When brain glutathione levels dropped, pH values rose in these patients brains

3.4.13.19) is the enzyme that hydrolyzes dipeptides, including cysteinylglycine compounds, such as the oxidized -glutamyltranspeptidase product cystinyl-bis-glycine and the conversion of leukotriene D4 to E4 [48]

Simultaneously, advances in our understanding of the gut-brain axis and neuroimmune pathways have expanded the therapeutic landscape to include microbiota-targeted strategies and modulation of systemic inflammation

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doi: 10.1073/pnas.1424638112