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Os estudos de toxicidade aguda e subcrnica em ratos no revelaram toxicidade significativa nas doses teraputicas estudadas

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More importantly, the persistent DNA damage environment induced by 8-OHdG is considered a major driver of the high frequency of MED12 gene mutations [112]

Nausea was more frequent with tirzepatide vs placebo, especially with tirzepatide 15 mg (OR 5.60 [95% CI 3.12, 10.06]), associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59]) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85])

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