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SFN displays an immunosuppressive effect on ex vivo T-cells from RA patients and provokes ROS production in whole blood lymphocytes Low ROS levels in RA patient-derived T-cells were linked to biased differentiation of T-cells into IFN- and IL-17-producing inflammatory cells (37), increases bone resorption during RA
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At the same time, Zn supplementation was also associated with improvement of lipoprotein profile (decreased ApoB/ApoA1, oxLDL, total cholesterol and LDL-cholesterol values) and reduced leptin levels [19]
Apr 2013;81(4):731-737
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