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Calculation Framework for Effective Delivery Cost (TCO) A proposed internal framework for evaluating effective delivery cost can be expressed as: *SAG estimate based on prodrug mechanism

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Separation was conducted at a constant temperature of 30 C using a mobile phase of 5% (v/v) acetonitrile, 0.05% (v/v) trifluoroacetic acid, and 0.1 M sodium perchlorate at a flow rate of 0.5 mL/min

Ilisso, C

Corbould, A., Kim, Y