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However, it's important to note that human clinical evidence is still limited, and responses can vary widely

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In July 2021, the FDA issued Ardelyx a Complete Response Letter in which it stated that the molecules effect size was small and of unclear clinical significance. Then, in November 2022, an FDA advisory committee voted 9-4 that Xphozahs benefits outweighed its risks

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Good candidates typically have a BMI over 30, or a BMI of 27 or higher along with one or more weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol