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When acetaminophen is taken in toxic amounts, the liver produces a damaging metabolite called NAPQI

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The heterogeneity of zones allows cells to perform specific functions effectively in response to various injuries

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Front Pharmacol 13:876868 Bjrnsson ES (2021) Clinical management of patients with drug-induced liver injury (DILI)

k 1 in the stylized model is representative of the rate constant, , which regulates the efflux of methionine from cytosol into blood