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Notably, in the db/db- and the HG-treated SV40-MES-13 cells, the protective effect of astragaloside I on drug-induced renal fibrosis mediated by the Klotho/TGF-1/Smad2/3 pathway can be offset by the ITSA-1 (a HDAC3 agonist) (Zhang X

Purcell K, Sumithran P, Prendergast LA, Bouniu CJ, Delbridge E, Proietto J

J Pediatr Endocrinol Metab (2020) 33:94750

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