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doi: 10.1101/cshperspect.a006072 23 JohnattyS

Proc Natl Acad Sci USA 111 , E12111220, doi:10.1073/pnas.1321347111 (2014)

Furthermore, NADP + cannot serve as a substitute for the employed NAD + cofactor of MDH

DOI: 10.1097/JU.0000000000003999

Clinical trial data shows retatrutide producing greater weight reduction (24.2% vs approximately 20-22%) and more dramatic liver fat reduction (82.4% vs approximately 50-60%) compared to tirzepatide

Clinicians should focus on established adverse effects such as gastrointestinal symptoms, pancreatitis risk, and thyroid considerations rather than unsubstantiated neurological concerns