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TMCC1 functions to stabilize the MCS, and its depletion leads to defective cargo trafficking from late endosomes to the Golgi apparatus

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Now, Amylin, also known as IAPP (Islet Amyloid Polypeptide), is a 37-amino acid peptide co-secreted with insulin at a roughly 100:1 ratio

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This could then lead to uracil misincorporation into DNA during replication or repair, and cause DNA damage, including point mutations and strand breaks (111)