Clinical studies have documented that GLP-1 receptor agonists slow gastric emptying, particularly during initial therapy and dose titration, though this effect may attenuate somewhat over time
So simple and if I have questions they are quick to answer
KPV's anti-inflammatory effects gradually diminish over 1-2 weeks after cessation, so underlying inflammatory conditions may slowly return without the active NF-kB suppression
But the addition of glucagon receptor agonism overwhelms the GIP benefit
Side effects like nausea, reflux, constipation, or sulfur burps often improve with hydration, smaller bland meals, and avoiding heavy, spicy, or sulfur-rich foods
SGLT-2 inhibitors offer numerous benefits to patients with type 2 diabetes and kidney disease (Box 1)