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Common side effectsnausea, vomiting, and constipationoccur in a subset of users and typically resolve within weeks as the body adjusts

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This may lead people to wish to take multiple drugs that induce weight loss simultaneously

Moreover, the observed high incidence of MACEs, which reached 12.0% in the non-users during follow-up, highlights the elevated cardiovascular risk among KTRs with T2DM, underscoring the importance of incorporating GLP-1 RAs into the DM care for these specific population

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This has led to the development of semaglutide, currently considered as state-of-the-art for GLP-1 RAs