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Understanding which patients are candidates for GLP-1RAs treatment will be key, according to Lorenzo Leggio, MD, PhD, clinical director of the National Institute on Drug Abuse

What the research shows: In the SURMOUNT clinical trials, patients taking tirzepatide lost an average of 2022% of their body weight over 72 weeks

For people with diabetes taking GLP-1s, kidney function markers like urine albumin-to-creatinine ratio may improve, suggesting kidney protective effects, though the magnitude of benefit is less than with some other diabetes medications like SGLT2 inhibitors

[DOI] [PubMed] [Google Scholar] 124.Furbee J.W., Jr., Francone O., Parks J.S

Whilst GLP-1 receptors have been identified in cardiac tissue, their functional significance and contribution to heart rate changes are not yet fully understood

On a GLP-1 medication with reduced food intake, this fear becomes counterproductive