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The irritation requires stopping use, waiting for recovery, and restarting at appropriate levels, wasting both time and product

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Furthermore, 40.4% of ICSRs involved hospitalized patients, 2.7% resulted in patient mortality, 0.9% led to disability, and 2.8% caused life-threatening reactions, while only 1.7% classified as non-serious outcomes

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PCSK9 inhibitors provide modest but durable Lp(a) lowering in routine practice, with wide inter-patient variability and greater absolute benefit in those starting with the highest levels

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