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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

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Drug-induced disorders of glucose metabolism

High-dose oral glutathione or liposomal glutathione (a formulation designed for better absorption) might be next in line to try

A standard moisturizer mainly seals in water