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Despite the preclinical promise shown by pharmacological agents that target ferroptosis-such as inducers like erastin and RSL3, and inhibitors like fer-1-their application in clinical settings encounters difficulties, which include unintended effects and restricted tissue specificity [2, 99]
There have been multiple randomised controlled trials and systematic reviews that have explored this
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Every injection delivers what it should
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Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]
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