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c) coupling, optionally protected Aib and His amino acid, d) acylating an epsilon amino group of lysine residue in semapeptide with an acylating agent of Formula (V), which is optionally activated, In an aspect of fourth embodiment, optionally protected Aib is selected from Fmoc-Aib-OH and optionally protected His amino acid is selected from Boc-His(Boc)-OH

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The study is of very good quality, published in a journal of the highest prestige in the scientific field, such as Nature Medicine

Mohamed, K