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In the 2021 trial of 1,973 patients, tirzepatide led to a 2-5% greater incidence of these gastrointestinal adverse events.3 Semaglutide Most accessible peptide for weight loss, with a lower side effect risk Pros Most widely available GLP-1 treatment for weight loss Has led to dramatic weight loss in clinical studies Less risk of side effects compared to tirzepatide Usually only a once-a-week administration Cons Not as effective for weight loss as tirzepatide according to the scientific literature Semaglutide may not have the double-duty action of tirzepatide, but its still a highly effective treatment for achieving rapid weight loss

Gut Microbes, 11(3), 465-480

Kuwabara, M