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When blood glucose rises after a meal, GLP-1 and GIP both stimulate insulin secretion from pancreatic beta cells

no human cases confirmed) Long-term Safety: SELECT trial demonstrated 5+ year cardiovascular safety Key Difference: AOD-9604 may have a cleaner tolerability profile (no GI effects), but efficacy failure makes this advantage clinically irrelevant

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

For others, it might take a few weeks, depending on how severe the deficiency was, to begin with

D., Abtahi, S., Kuo, W

It can serve as an alternative delivery method, but it is not a direct replacement