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The MHRA has approved these medications for specific indications, and NICE guidelines recommend their use in adults with type 2 diabetes who meet certain criteria (NG28)

doi:10.1111/head.14618 [DOI] [PubMed] [Google Scholar] 26.Farr OM, Sofopoulos M, Tsoukas MA, et al

ClinicalTrials.gov registration: NCT01947595)

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reported modest impact on the liver with long-term targeting strategies (22, 24), suggesting that acute treatments targeting DPP4 more readily influence mouse lipid metabolism than long-term deletion of DPP4, which may be prone to metabolic adaptation

Despite the novelty of this study, several limitations exist