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Metformin is usually a first-line medication because the pill is easy to take and it's affordable

The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo

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It has demonstrated beneficial effects in treating energy impairments in several neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease (reviewed by Adhihetty and Beal, G93A mice prevented loss of motor neurons, protected neurons from oxidative damage in the spinal cord, and improved motor performance and survival of mice in a dose dependent manner (Klivenyi et al., 1999)

It also has the added benefit of a once-monthly dosing, as opposed to the much more frequent dosing required for the mainstay epoetin alfa treatment (Besarab 2012)

Phentermine , another popular option, is often prescribed for short-term use and works as an appetite suppressant