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400 The underlying neuroprotective mechanisms involve increased levels of miR-21, miR-27a, and miR-146a, along with decreased expression of target proteins

Villarama C, Maibach H

Starr R

Research shows that both moderate-intensity continuous training (MICT, 50%70% VO 2 max) and high-intensity interval training (HIIT, 85%95% VO 2 max) can effectively activate the Nrf2 pathway, with HIIT being 30%40% more effective in upregulating antioxidant enzymes than MICT (Martinez-Canton et al., 2024)

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At this level, doses are usually divided throughout the day and paired with vitamin C to support glutathione recycling and effectiveness