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Compliance with Ethics Guidelines This article is based on opinions of leading experts and does not contain any studies with human participants or animals performed by any of the authors

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AIM2 suppresses ferroptosis by promoting proteasomal degradation of FOXO3a, a transcriptional activator of ACSL4 a key enzyme that esterifies PUFAs into peroxidation-prone phospholipids essential for ferroptosis execution (259)

Proper administration was crucial to avoid mediocre results

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The amino acid glutamine was first considered to be a biologically important molecule more than 100 years ago, when it was suggested on the basis of indirect evidence that glutamine may occur as a structural component of proteins