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Retatrutide is the heavyweight, a triple agonist that recruits the GLP-1, GIP, and glucagon pathways in a single molecule

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It has been shown to attenuate ROS generation, restore barrier function, and modulate NF kappa B, iNOS and related molecular pathways involved in oxidative and inflammatory injury [12, 13]

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It alters the kynurenine pathway to mitigate inflammation-linked neurotoxicity, a mechanism demonstrated by its ability to prevent the reduction of hippocampal neurogenesis induced by pro-inflammatory cytokines (such as IL-1) [28] and can reset the HPA axis, reducing stress-related neuronal damage