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The STEP trials provide strong evidence that semaglutide 2.4 mg reduces body weight and improves numerous health complications associated with obesity

by Veronica Reed 24 Jun 2026 at 8:59am Q

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Injection should only occur 1 time per week

if your procedure was major or your recovery was complicated, your care team may recommend waiting longer

What to Do If Semaglutide Is Not Working If you are not losing weight on semaglutide, consider the following before assuming the medication is ineffective: Check your titration timeline Significant weight loss typically becomes apparent from weeks 812 onward, not in the first four weeks