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Elevations of these organic acids (OA) reflect dysfunction in specific metabolic pathways

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These new studies show small relative NAION risk with GLP-1s mostly in T2D patients (RR ~1.7-2.5), but absolute risks are very low (~0.02-0.08% over years) and attenuated after diabetes adjustment, suggesting confounding more than causation

TN41 represents a genuinely novel mechanistic approach to follicle activation research, but current evidence comes from a single published study in animal and cell models

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doi: 10.3389/fendo.2025.1575087 148 Al-ObaideMAISinghRDattaPRewers-FelkinsKASalgueroMVAl-ObaidiIet al