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Therefore, the contribution of daily insulin dose reduction to weight loss appeared almost negligible, and the mechanisms underlying this effect are not completely understood

A 2023 retrospective analysis of patients on dual therapy noted that combination use was associated with greater weight loss at 24 weeks compared to either agent alone, though patient selection and adherence were not standardized

Allulose is generally safe and well-tolerated in reasonable amounts (under 25 grams daily)

however, we do not expect misclassification to be differential between the groups

Cruciat, G

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