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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )
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[DOI] [PubMed] [Google Scholar] 65.Gunawan F., Nassif M.E., Partridge C., et al
Additionally, copper may inhibit the p97-Npl4 complex, which is essential for protein degradation, thereby exacerbating underlying proteotoxic stress [60]