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Vitamin B12 is vital for human life due to its role in making red blood cells and supporting the function of the brain and nerves

307,308 Additionally, GLP-1R signaling may affect other macrophage functions, such as phagocytosis, migration, and cell survival

Darmaun D, Smith SD, Sweeten S, Hartman BK, Welch S, Mauras N

"Mitochondrial DNA mutations in disease and aging." Environmental and Molecular Mutagenesis, 2010

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Covalent functionalisation forms stable bonds via amidation, esterification, or silylation, ensuring durable conjugation for drugs, proteins, or imaging agents, whereas non-covalent approaches rely on stacking, electrostatic interactions, adsorption, or chelation, ensuring reversible binding, well-suited for stimuli-responsive delivery [33]