Animal studies have reported various effects, including potential lifespan extension in rodent models and improvements in certain biomarkers associated with aging
Drug metabolism represents a more specialized subset of xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") which also covers other foreign organic compounds such as pollutants or poisons in wider group of organisms that includes microorganisms, fungi, plants and animals
Conclusion Clinical trials show that GLP1 medications can produce meaningful weight loss, averaging 10 to 22% of body weight depending on the medication and dose
p = 0.01 for superiority) over ~4 years in 9,340 patients with established CVD or CV risk factors (5)
Diabetes Care 43(Suppl 1):S98S110
Exclusion criteria included diagnosis of type 1 diabetes, pregnancy, use of any GLP-1 RA or DPP4i during the baseline period, use of 2 types of products in the index drug class on the index date, initiation of another new glucose-lowering drug class on the index date, bariatric surgery, or use of antiobesity medications during the study period
