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Int J Mol Sci 22(11):5662

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Although corticosteroids and biologics have shown clinical benefits, their long-term use is often constrained by high costs, adverse effects, heterogeneous patient responses, and limited applicability across AD subtypes

Owing to the high cost of components such as cysteine and yeast extract, the original YCK50D medium formulation was considered economically unsuitable for large-scale industrial fermentation

Finally, there were safety and generalizability limitations