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In their study, rats with TBI underwent daily 15-min stimulations over a continuous 14-day period through dense-disperse waves at a frequency of 1 Hz, along with a combination of acupuncture points

AC system activation generates an increase of the intracellular secondary messenger, cyclic adenosine monophosphate (cAMP), through the conversion of adenosine triphosphate, which then results in the activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) [32,33,34,35]

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For the SJ, the relative change in males from Wk5-Pre to Wk5-Post was significantly greater in the CAR group compared to the PLA group (mean diff = 2.1