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Similarly, pooled analyses from cardiovascular and cancer prevention trials reported relative risks close to unity (RR = 0.94-1.04), confirming a lack of protective effect from antioxidant supplementation in the general population (345)

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However, at 15 g doses of l-citrulline, a lower fractional absorption rate and plasma retention of l-citrulline was observed, potentially due to saturation of its transporters (e.g., ASC or B 0,+ -amino acid transporters) or reduced renal conversion of l-citrulline to l-arginine

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