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Common causes: diabetes, hypertension, chronic glomerulonephritis, polycystic kidney disease

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The radioprotection studies of DHS were carried out in a mice model wherein intraperitoneal administration of DHS (2 mg/kg body weight for five consecutive days before irradiation and three times per week during the post-irradiation period) showed significant improvement in the 30-day survival against the lethal dose (8 Gy, -rays) of WBI (Table 2) [64]

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Regardless of the initial etiology (metabolic, alcoholic, or viral), progression to advanced SLD and HCC is governed by critical shared pathways, which are systemic metabolic dysregulation and inflammation