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Additional information Statement of Financial Support This study was enabled by funding from the Netherlands Organisation for Health Research and Development ZonMw (Grant number: 80-83600-98-10190)

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PMID 22179958

Magge is a member of the National Institutes of Health Human Studies of Diabetes and Obesity Study Section

It carries strategic Aib substitutions to resist DPP-4 cleavage and a C20 fatty di-acid chain at lysine-17 that drives reversible albumin binding extending the plasma half-life to roughly 6 days in published pre-clinical models and supporting once-weekly dosing protocols