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The Sucrosomial carrier system has been previously investigated for its potential to enhance the bioavailability of various nutrients, including iron, magnesium, and vitamin D3, providing a basis for its application in vitamin B12 supplementation

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Notably, excessive ROS can further exacerbate calcium homeostasis disorders by damaging the sarcoplasmic reticulum Ca-ATPase and mitochondrial calcium uniporter, forming a malignant cascade of excessive ROS-calcium imbalance-energy crisis [136]