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TLS most often occurs after the start of cytotoxic therapy in patients with high-grade lymphomas (particularly the Burkitt lymphoma subtype) and acute leukemias, or after treatment of large or fast-growing tumors

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Vitamin B1 (thiamine) serves as a coenzyme with transketolase enzyme in the pentose phosphate pathway of glycolysis

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Since the liver is essential in regulating one-carbon metabolism and may influence the immunological responses in newborn animals, this organ may be an exciting objective for studying the fetal programming effects influenced by dietary methyl donors, such as Met