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Furthermore there is also some limited and inconsistent evidence that changes in transporter activity may contribute to the reductions in UA seen in PD and these are reviewed below

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity

Sardinia MF, Hanesworth JM, Krishnan F, Harding JW