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Huang DQ, Sharpton SR, Amangurbanova M, Tamaki N, Sirlin CB, Loomba R, et al

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Both drug classes were equally effective in reducing combined major adverse cardiac events such as heart attack, stroke, and death from cardiovascular disease, compared to people with diabetes who were not taking the drugs.[3] The rate of hospitalization for heart failure was 32% less in patients taking SGLT2 inhibitors compared to patients not taking the drugs, especially in those with more severe cardiovascular disease risk

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Others find that a single dose adjustmentspreading medication across two smaller injections rather than onereduces symptom severity