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In addition, we observed that HIF-1 protein levels accumulate downstream of mTOR in response to GLP-1R signalling, whereas we also demonstrated that depletion of HIF-1 impaired effects on glycolysis and transcriptional regulation of glycolytic genes

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Taspoglutide prevents apoptosis in vitro , promotes -cell proliferation, and exerts multiple protective effects of -cell in Zucker Diabetic Fatty rats [20]

Because of its structural difference from natural GLP-1, it is not easy to be degraded by dipeptidyl peptidase-4 (DPP-4), thus prolonging the action time

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